Sep 10, · Breastfeeding can in some cases lead to chafing or chapped nipples that may be sore. The breasts overall, including the nipples, may be sore or tender at certain times in the menstrual cycle (typically just before the start of the menstrual period) or in early pregnancy. Other causes of nipple pain. Apr 11, · Not all women experience breast discomfort in the same way. The pain may feel sharp, stabbing, or throbbing. The same hormones that cause overall breast soreness during perimenopause may also lead.